ABSTRACT
Resumen Introducción: el colectivo venezolano residente en Chile ha aumentado en cantidad y en la vulnerabilidad social en que migran. Objetivo: analizar qué elementos sociodemográficos y económicos dificultan la realización de cuarentena en la población venezolana residente en Chile, considerando cómo esto varía según características como estar trabajando, tener seguro de salud, sexo y nivel educacional. Metodología: el diseño corresponde a un estudio cuantitativo observacional de corte transversal desde una encuesta online sobre COVID-19 a extranjeros en Chile, realizada en abril (2020), por medio de una estrategia de muestreo en "bola de nieve" (n=1,690 migrantes). Este análisis secundario se focaliza en participantes venezolanos (N=1,006), por medio de análisis descriptivo, bivariado y de regresión multivariada, con ajuste de Raking para disminuir el sesgo de auto-selección. De estos, el 49,6% fueron mujeres, y la mayoría (el 50%) tenía entre 30 y 49 años. Resultados: la probabilidad de no poder realizar cuarentena es mayor en quienes cuentan con trabajo ((OR=5,35, 95%IC (3,16-9,02)), en relación a los que no; en quienes no poseen previsión de salud ((OR=4,02, 95%IC (1,57-10,32)) y en los que tienen previsión pública (Fonasa) ((OR=3,92, 95%IC (1,84-8,35)), en relación a las personas con previsión privada; en hombres ((OR=2,23, 95%IC (1,50-3,32)) que en mujeres; y en los que tienen nivel educacional menor a nivel superior ((OR=1,74, 95%IC (11,50-3,32)). Conclusión: la asociación encontrada entre no cumplir cuarentena con condiciones laborales y tipo de seguro de salud expone la relevancia de la vulnerabilidad socioeconómica en las oportunidades de llevar adelante medidas de cuidado de salud pública en población migrante venezolana en Chile, como es el seguimiento de confinamiento durante una pandemia. Esto es importante para la planificación sanitaria en futuras crisis socio-sanitarias.
ABSTRACT Introduction: The Venezuelan group residing in Chile has increased in number and in the social vulnerability in which they migrate. Objective: To analyze which sociodemographic and economic elements make it difficult to carry out quarantine in the Venezuelan population residing in Chile, considering how this varies according to characteristics such as being working, having health insurance, sex, and educational level. Methodology: Cross-sectional observational quantitative study from an online poll on COVID-19 to foreigners in Chile, carried out in April (2020), through a "snowball" sampling strategy (n=1,690 migrants). This secondary analysis focuses on Venezuelan participants (N=1,006), through descriptive, bivariate and multivariate regression analysis, with Raking adjustment to reduce self-selection bias. Of these, 49.6% were women, and the majority (50%) were between 30 and 49 years old. Results: The probability of not being able to quarantine is higher in those who have a job ((OR=5.35, 95% CI (3.16-9.02)), in relation to those who do not; in those who do not have a health insurance ((OR=4.02, 95% CI (1.57-10.32)) and in those who have public insurance (i.e. Fonasa) ((OR=3.92, 95% CI ( 1.84-8.35)), in relation to people with private pension; in men ((OR=2.23, 95% CI (1.50-3.32)) than in women; and in those with a lower educational level at a higher level ((OR=1.74, 95% CI (11.50-3.32)). Conclusion: The association found between not complying with quarantine due to working conditions and type of health insurance exposes the relevance of socioeconomic vulnerability in the opportunities to carry out public health care measures in the Venezuelan migrant population in Chile, such as monitoring of confinement during a pandemic. This is important for health planning in future socio-health crises.
ABSTRACT
Drug disposition in the human body is strongly influenced by transporters and metabolizing enzymes expressed in key organs including intestine, liver and kidney. Since drugs and chemicals present in foods such as fruit juices and herb-based products are substrates of the above-mentioned proteins, there is a high probability of pharmacokinetic interactions. Findings from preclinical and clinical studies helped to characterize the mechanisms by which the components of fruit juices and herbs act as perpetrators of pharmacokinetic interactions. The aim of this review is to provide an overview of pharmacokinetic fruit juice- and herb-drug interactions that could be relevant in the clinical setting.
Subject(s)
Humans , Plant Preparations/adverse effects , Fruit and Vegetable Juices , Herb-Drug Interactions , FruitABSTRACT
En los últimos años el aumento de la prevalencia de obesidad y diabetes mellitus tipo 2 (DM2), la aparición a edades más tempranas de DM2, así como el desplazamiento del embarazo a edades mayores conllevan a un aumento de casos de diabetes (DM) en el embarazo. En algunas pacientes la diabetes no se diagnostica y obviamente no se trata. Este hecho puede complicar un embarazo, especialmente en el período embriogénico. La aplicación de nuevos criterios de diagnóstico para la diabetes gestacional, la controversia en el uso y la seguridad de los antidiabéticos orales durante el embarazo, así como el uso de determinados análogos de insulina hacen indispensable que Latinoamérica, a través del Grupo de Trabajo de Diabetes y Embarazo de la Asociación Latinoamericana de Diabetes (ALAD), actualice sus recomendaciones. El desarrollo de las mismas se realizó en varias reuniones y trabajo conjunto del grupo. Se tuvo en cuenta el grado de nivel de evidencia, la experiencia de los referentes y la adaptación cultural según las regiones donde se implementarán las recomendaciones descriptas
Subject(s)
Diabetes, Gestational , Glucose , Glucose Tolerance Test , PregnancyABSTRACT
Thrombotic thrombocytopenic purpura, an immune/non-immune thrombotic microangiopathy (TTP/TMA) is associated with high morbidity and mortality, even with appropriate treatment. In patients refractory to standard treatment with plasmapheresis there is no certainty about the best therapeutic strategy. This report shows our experience in eight refractory patients who survived after treatment with rituximab.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Purpura, Thrombotic Thrombocytopenic/drug therapy , Rituximab/therapeutic use , Recurrence , Retrospective Studies , Rituximab/pharmacokineticsABSTRACT
We have treated 28 patients (pts) with malignant hematological diseases with allogenic bone marrow transplantation (BMT). 18 pts had acute lymphoblastic (ALL) and non lymphoblastic leukemia (ANLL), 5 chronic myeloid leukemia (CML), 2 severe aplastic anemia (SAA), 1 myelodisplasia, 1 Fanconi's anemia and 1 advanced Non Hodgkin's lymphoma. All but three received the graft from HLA identical sibling donors. We used conditioning with total body irradiation and chemotherapy (cyclophosphamide, cytarabine and etoposide) in 17 pts and chemotherapy alone in 11.24 pts had a full hematological recovery 18 to 25 days post BMT. 15 pts died after BMT as a consequence of toxicity or early infection (4), graft failure (2), graft vesus host disease (4) or relapse (5). Actuarial event free survival for the group with favorable prognosis (SAA, ALL and ANLL in first or second remission and CML in chronic phase) is 57 percent at 36 months. Allogeneic BMT is an effective and feasing therapeutic procedure for selected patients with hematological malignancies